Protective effects of Sparstolonin B, a selective TLR2 and TLR4 antagonist, on mouse endotoxin shock
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چکیده
منابع مشابه
P 147: Role of Sparstolonin B in Intracerebral Hemorrhage-Induced Inflammatory Brain Injury: Blocking the Formation of TLR2/TLR4 Heterodimer
Intra-cerebral hemorrhage (ICH) is a particularly severe type of stroke accounting for 10–15 % of all strokes and is associated with a mortality rate of 30–50%. Neuroinflammation contributes to ICH-induced secondary brain injury and understanding the mechanisms causing neuroinflammation can be helpful to find new treatments of ICH. Recent studies demonstrated that toll like receptor...
متن کاملA cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression
Toll-like receptors (TLRs) function as primary sensors that elicit coordinated innate immune defenses through recognition of microbial products and induction of immune and proinflammatory genes. Here we report the identification and biological characterization of a lipopolysaccharide (LPS)-like molecule extracted from the cyanobacterium Oscillatoria Planktothrix FP1 (cyanobacterial product [CyP...
متن کاملThe Anti-angiogenic Effects of Sparstolonin B
Sparstolonin B (SsnB) is a novel bioreactive compound isolated from Sparganium stoloniferum, an herb historically used in Traditional Chinese Medicine as an anti-tumor agent. SsnB has demonstrated anti-inflammatory properties, inhibiting Toll-like receptor mediated inflammation in isolated macrophages and in mice. Angiogenesis, the process of new capillary formation from existing blood vessels,...
متن کاملp 147: role of sparstolonin b in intracerebral hemorrhage-induced inflammatory brain injury: blocking the formation of tlr2/tlr4 heterodimer
intra-cerebral hemorrhage (ich) is a particularly severe type of stroke accounting for 10–15 % of all strokes and is associated with a mortality rate of 30–50%. neuroinflammation contributes to ich-induced secondary brain injury and understanding the mechanisms causing neuroinflammation can be helpful to find new treatments of ich. recent studies demonstrated that toll like receptor 2 (tlr2) fo...
متن کاملeffects of first language on second language writing-a preliminary contrastive rhetoric study of farsi and english
to explore the idea the investingation proposed, aimed at finding whether the performances of the population of iranians students studying english in an efl context are consistent in l1 and l2 writing taks and whether there is a cross-linguistic transfer in this respect. in this regard the subjects were instructed to write four compositions-two in english and two in farsi-which consisted of an ...
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ژورنال
عنوان ژورنال: Cytokine
سال: 2015
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2014.12.003